Can You Die From Depression?

Depression might seem like just a mental disorder, but it can affect both the mind and body. When left untreated, it can impact basic functioning, damage physical health, and lower your quality of life. 

So, can you die from depression? According to research, approximately 3.5% of deaths in the United States are linked to depression or anxiety disorders. However, depression isn’t a direct cause of death. That said, it can become life-threatening without the proper treatment or interventions. 

Here’s what you need to know about depression, its risks, and how you can minimize those risks.

What Happens if Depression is Left Untreated?

Depression usually doesn’t go away on its own without some kind of intervention, like medication, therapy, or healthier habits. Without support, your symptoms can worsen and affect your ability to function in your day-to-day life. Common symptoms of depression include: 

  • Constant feelings of sadness numbness, or hopelessness
  • Feeling intense guilt, shame, or feeling like a burden
  • Irritability or emotional outbursts
  • Difficulty concentrating or making decisions
  • Low energy or sluggishness
  • Insomnia or oversleeping
  • Changes in appetite
  • Thoughts of self-harm or suicide
  • Unexplained physical aches and pains

Over time, untreated depression affects the brain and body in that it weakens your immune system and heart function, while also making you more vulnerable to other health conditions. 

Increased Risk of Suicide

In the U.S., depression contributes to more than two-thirds of the 30,000+ suicides reported each year. Among patients with untreated major depressive disorder (MDD), the lifetime risk of suicide is almost 20%. Warning signs of suicide risk include: 

  • Talking about wanting to die or feeling like a burden
  • Withdrawing from others or isolating
  • Engaging in risk-taking behaviors or substance abuse
  • Giving away possessions or saying goodbye
  • Searching online for ways to die or making a plan

If you’re having thoughts of suicide, help is available. The following are free, confidential resources that are here to support you in your time of need: 

Health Complications

Studies have found that those with chronic physical illnesses are more likely to have depression than those without another condition.  

Related Illnesses

Depression not only affects your mood, but it also affects your immune system, inflammation, heart rate, and how your body handles stress. In fact, it’s highly prevalent in those with chronic diseases. 

In 2019, chronic diseases killed almost 41 million people, which accounts for 75% of deaths worldwide. When you add depression on top of a chronic illness, you’re not only juggling the pain and discomfort from your physical condition, but you’re also faced with depression symptoms. These symptoms can make it difficult to properly take care of your chronic illness, thus contributing to its progression. 

To put the relationship between chronic illnesses and depression into perspective, the CDC found the following populations to be living with both conditions:

  • 51% of Parkinson’s patients
  • 42% of cancer patients
  • 27% of diabetes patients
  • 23% of cerebrovascular patients
  • 17% of cardiovascular patients
  • 11% of Alzheimer’s patients

A specific example of this relationship is diabetes. Around 37 million Americans have diabetes, and they’re 2 to 3 times more likely to develop depression than those without it. Even worse, diabetics with depression face a 46% higher risk of death from all causes than diabetics without depression.  

Changes in Appetite

Depression can affect your appetite, but not always in the same direction. Some people lose interest in food entirely and will skip meals without even realizing it. Others may turn to food for comfort, which leads to more cravings and overeating. 

A recent study found that 13% of participants with MDD had lifelong eating disorders, and 39% showed clinically significant disordered eating behavior. In comparison, just 3% and 11% of participants without depression showed the same patterns. 

If left untreated, appetite changes can cause extreme fluctuations in weight, malnutrition, or obesity. In 2019, there were an estimated 5 million deaths worldwide related to obesity. Malnutrition deaths came to 251,577. 

Whether someone is under-eating, over-eating, or fluctuating between the two, their physical health can decline quickly if they’re struggling with depression.

Substance Use

Depression can leave you feeling numb or disconnected from the world, which is why many depressed individuals might consider turning to substances to try and cope. This is called self-medication, and while it may temporarily make you feel better, it can actually worsen your symptoms and increase health risks. 

Surveys have found that almost half of those with a mental illness will also experience a substance use disorder and vice versa. Common substances used to self-medicate include marijuana, alcohol, and opioids. 

Struggling with both substance use and depression can have serious consequences. Recent findings show that when psychiatric disorders and substance abuse occur together, the chances of dying prematurely go up significantly. Suicide was found to be the leading cause of death in these cases.

How is Depression Treated?

Depression is highly treatable despite its risks. The most common treatment options include therapy, medication, and newer interventions like brain stimulation. Here’s a look at each type of treatment: 

Therapy

Cognitive Behavioral Therapy (CBT) is considered the gold standard for depression treatment. It focuses on how your thoughts, behaviors, and emotions are connected, while helping you break negative patterns. CBT: 

  • Teaches people to identify and reframe unhealthy thought patterns 
  • Builds problem-solving skills for everyday challenges
  • Encourages facing fears instead of avoiding them
  • Focuses on present-day issues rather than the past

Studies have found that CBT reduces the risk of MDD recurrence by 50% after 12 months and 24% after 24 months. 

Medication

Antidepressants stabilize the levels of brain chemicals in your brain, including serotonin and norepinephrine. Commonly prescribed medications are Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). 

In a recent study, researchers found that 50 out of 100 people taking antidepressants saw improvement in their symptoms within 6-8 weeks. This compares to only 30 out of 100 people taking a placebo. 

Keep in mind, medication can reduce symptoms and help prevent relapse, but it’s not a guaranteed cure. 

Brain Stimulation Therapies

Unfortunately, not everyone will respond to standard depression treatments. This is known as treatment-resistant depression (TRD), and it has a 1.9x higher risk of suicide compared to non-TRD patients. 

In these cases, other treatments may be considered, including transcranial magnetic stimulation (TMS). TMS is a non-invasive procedure that uses magnetic pulses to stimulate brain activity. It’s becoming a favorable option due to its minimal side effects and tolerability. 

Clinical response and remission rates support TMS as a viable depression treatment per the following scales: 

  • Clinical Global Impression-Severity scale (CGI-S) showed a response rate of 58.0% and a remission rate of 37.1%.
  • Inventory of Depressive Symptomatology, Self-Report (IDS-SR) had a response rate of 41.5% and a remission rate of 26.5%.
  • 9-Item Patient Health Questionnaire (PHQ-9) showed a response rate of 56.4% and a remission rate of 28.7%. 

How to Cope with Depression

Professional treatment is essential for treating your depression; however, there are some things you can do on your own to support treatment. These include: 

  • Practicing self-compassion and avoiding negative self-talk
  • Using journaling to process emotions and track patterns
  • Trying meditation, breathwork, or progressive muscle relaxation
  • Maintaining a consistent sleep schedule
  • Staying physically active
  • Connecting with others
  • Joining an online or in-person support group
  • Limiting alcohol and substance use 

Take Control of Your Mental Health 

Depression is more than emotional pain. It can affect your overall health in profound ways, and if left untreated, it can be life-threatening. 

If you’re experiencing symptoms of depression, don’t wait until it’s too late. Contact Cura Behavioral Health to speak with a licensed mental health professional. Whether you need therapy or medication, getting help now could save your life. 

Sources: 

Trends and Factors Associated With the Mortality Rate of Depressive Episodes: An Analysis of the CDC Wide-Ranging Online Data for Epidemiological Research (WONDER) Database – Cureus 

 Suicide Statistics – Depression and Bipolar Support Alliance 

988 Lifeline 

The Trevor Project 

Veterans Crisis Line 

Combined Effects of Depression and Chronic Disease on the Risk of Mortality: The Korean Longitudinal Study of Aging (2006-2016) – Journal of Korean Medical Science 

Understanding the Link Between Chronic Disease and Depression – National Institute of Mental Health 

Chronic diseases cause 75 percent of all deaths globally. The toll is likely to rise. – Vox 

The Intersection of Mental Health and Chronic Disease – Johns Hopkins Bloomberg School of Public Health 

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective – Impact of DHA/EPA and Other Nutrients on Development: From Perinatal to Menopause 

Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019 – eClinicalMedicine 

Common Comorbidities with Substance Use Disorders Research Report – National Institutes on Drug Abuse 

Association of substance use and other psychiatric disorders with all-cause and external-cause mortality in individuals given community sentences in Sweden: a national cohort study – THE LANCET Regional Health Europe 

Does cognitive behavioral therapy reduce the recurrence of depression? – Evidence-Based Practice 

Depression: Learn More – How effective are antidepressants? – InformedHealth .org 

Cause-specific mortality in treatment-resistant major depression: Population-based cohort study – Journal of Affective Disorders 

Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: Recent Critical Advances in Patient Care – Current Treatment Options in Psychiatry 

Is TMS Therapy Right for You?

Determining if TMS therapy suits your mental health journey should involve consultation with a qualified professional. At Cura Behavioral Health, we provide comprehensive assessments to help you make informed treatment decisions.

Begin Your Transformation Today

Don’t let a mental health condition hold you back any longer. Schedule a consultation with Cura Behavioral Health today. Our experienced team is ready to answer your questions and create a personalized treatment plan tailored to your unique needs.

Dr. Kevin Simonson

Dr. Kevin Simonson, an esteemed Medical Director at Cura Behavioral Health, brings over 15 years of experience in psychiatry. A graduate from a top medical school, he specializes in the treatment of mood disorders and anxiety, employing a patient-centered approach. His dedication to evidence-based care and his commitment to advancing mental health practices have made him a respected figure in the field. Dr. Simonson’s leadership ensures the highest standard of care for the community at Cura Behavioral Health.